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We considered allopurinol compared with placebo as the main comparison, and present results fully below.

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For continuous outcomes, the NNTB and NNTH will be calculated using the Wells calculator software available at the Cochrane Musculoskeletal Group (CMSG) editorial office.

The allopurinol dose varied between 300 mg daily (; ) and either 100 to 300 mg (), or 200 to 300 mg daily depending on renal function ().

This is consistent with our results comparing allopurinol with febuxostat 120 and 240 mg for acute gout attacks and our results comparing allopurinol with febuxostat 80, 120 and 240 mg for achieving the target serum urate.

If you have missed your dose, take it as soon as you remember.

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This medication is used to reduce intense pain, inflammation and stiffness caused by conditions like osteoarthritis, rheumatoid arthritis, psoriatic arthritis, etc.

We will include the core domains nominated for chronic gout which include acute gout attacks, serum urate, pain, health-related quality of life (HRQoL), and function.

Always consult your doctor or healthcare specialist for medical advice.

Of the 16 initially infected and placebo-treated dogs, 14 (87.

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Gout results from abnormal deposits of uric acid crystals in the joint cartilage.

In addition to the absolute and relative magnitude of effect provided in the 'Summary of findings' table, for dichotomous outcomes, number needed to treat to benefit (NNTB) or the number needed to harm (NNTH) will be calculated from the control group event rate (unless the population event rate is known) and the RR using the Visual Rx NNT calculator ().

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There were no between-group difference in the percentage reduction in tophus area at final end point (12 months) with 50% for participants on allopurinol 200 or 300 mg daily, 83% for participants on febuxostat 80 mg daily and 66% for participants on febuxostat 120 mg daily ().

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Use of azathioprine or 6-mercaptopurine on the background of allopurinol permits a 4-fold reduction in their doses.

In the beginning of January 2015, we were called about a dog that was severely hit by a car and was laying in the same place for a whole day, slowly dying in the cold and snow.

Higher therapeutic plasma oxypurinol concentrations might be required for gouty patients with chronic kidney disease.

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There are two unpublished reports and one published paper of women giving birth to normal offspring after receiving Allopurinol during pregnancy.

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Elderly participants can present with more associated conditions and possibly a greater chance of adverse effects (), while reports indicate that gout in women may have different epidemiological and clinical characteristics compared with gout in men ().

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In addition, the study by was limited by the short duration (four months) while the trial had limitations related to the variable duration of follow-up.

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The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider.

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With the simultaneous administration of this drug and azathioprine or mercaptopurine it is observed accumulation of the latter in the body, because in connection with the activity of xanthine oxidase inhibition with allopurinol necessary to biotransformation of drugs, slowing their metabolism and elimination.

We could pool AEs for up to four trials depending on the dose of febuxostat in the control group.

There was low-quality evidence that there may be no difference in tophus regression between allopurinol up to 300 mg daily and febuxostat 80 mg daily.

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We will include all randomised or quasi-randomised controlled clinical trials (RCTs or CCTs) comparing allopurinol with another therapy (placebo or other urate-lowering treatment) in adults with chronic gout.

Group 1: allopurinol starting dose 100 mg daily that increased by 100 mg each week to 300 mg daily.

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CCTs (; ), defined their study population as having gout using the ARA criteria (), while the remaining four used an alternative definition.

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The 'Summary of findings' tables show the three most clinically relevant comparisons, as deemed by the review authors (RS, AK, RB), including allopurinol versus placebo, allopurinol versus febuxostat and allopurinol versus benzbromarone.

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It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional.

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We also planned to compare the magnitudes of effect informally to assess possible differences in response to treatment by considering the overlap of the CIs of the summary estimates in the two subgroups with non-overlap of the CIs indicating statistical significance.

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Take your allopurinol regularly if you want to keep away from gout attacks.

If you happen to miss a dose of this medicine, take it as soon as you remember.

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Single studies reported no difference in pain reduction when allopurinol (300 mg daily) was compared with placebo over 10 days, and no difference in tophus regression when allopurinol (200 to 300 mg daily) was compared with febuxostat (80 mg daily).

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While people react differently to PRISTIQ, in clinical studies there was a low occurrence of sexual side effects in men and women taking PRISTIQ 50 mg, similar to those who took placebo (sugar pill).

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However, the initiation of urate-lowering therapy has been associated with an increased incidence of acute gout attacks and, therefore, flare prophylaxis (with non-steroidal anti-inflammatory drugs or colchicine) during this period is recommended.

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However, about 2% of people develop hypersensitivity reactions (), and 20% of those are severe, including rash, toxic epidermal necrolysis, hepatitis, interstitial nephritis and death ().

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An increase in acute attacks of gout has been reported during the early stages of administration of Allopurinol, even when normal or subnormal serum uric acid levels have been attained.

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The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Rarely, a patient may develop varying degrees of bone marrow depression, affecting one or more cell lines, while receiving Allopurinol alone.

These findings may begin to change our current clinical practice from delaying the initiation of urate-lowering therapy until after the acute attack has settled, to starting urate-lowering treatment during an acute attack of gout.

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Your health care professional may want to reduce your dose slowly to help avoid these side effects.

We included 11 trials (4531 participants) that compared allopurinol (various doses) with placebo (two trials); febuxostat (four trials); benzbromarone (two trials); colchicine (one trial); probenecid (one trial); continuous versus intermittent allopurinol (one trial) and different doses of allopurinol (one trial).

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Disagreements will be resolved by consensus; if a consensus cannot be reached, a third review author (CE) will act as arbiter.

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It was therefore considered appropriate to analyse only those results which could be paired with a previous or subsequent investigation for analysis by Student's t-test"; "Allopurinol compliance was monitored by following serial blood uric acid levels.

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Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout.

Notre revue a révélé des preuves de qualité faible à modérée indiquant des effets similaires pour les abandons à cause d'EI et d'EIG et pour la fréquence des crises de goutte aiguës lorsque l'allopurinol (100 à 600 mg par jour) a été comparé à un placebo, à la benzbromarone (100 à 200 mg par jour) ou au fébuxostat (80 mg par jour).

Urate-lowering therapy reduces serum urate concentrations to subsaturating levels preventing the formation and deposition of urate crystals and consequently reduces the long-term manifestations of chronic gout.

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One open cross-over CCT compared allopurinol 300 mg daily with allopurinol 100 mg three times daily ().

Patients with decreased renal function require lower doses of Allopurinol than those with normal renal function.

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Duration of treatment was four months, and outcomes were assessed at two months (before dose escalation) (stage 1) and then at four months (after dose escalation) (stage 2).

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Participants in the allopurinol group received a starting dose of 100 mg daily, which increased by 100 mg each week to 300 mg daily, while participants in the benzbromarone group initially received 100 mg daily.

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One patient taking uricosuric therapy defaulted from follow-up and one left the district so that adequate follow-up was impossible.

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