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How far outside the realm of wellestablished science does a proposed treatment have to be before Katz will reject it as not worth considering as an option.

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Increasing the electron-withdrawing nature of the provides more potent inhibitory effect of norepinephrine uptake and improves the selectivity for norepinephrine over the serotonin transporter.

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To our knowledge, this is the first report to demonstrate improvement on the WPAI-AI, and the finding suggests that pain improvement with desvenlafaxine treatment was accompanied by greater functional activity.

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